Overfeeding kibble is a good place to start.
Blog Hyperlipid recently reported on a study done with dogs in an attempt to prove that saturated fat causes insulin resistance.
The goal of the study seemed noble enough:
the development of peripheral and hepatic insulin resistance relative to one another in the context of obesity-associated insulin resistance is not well understood. To examine this phenomena, we used the moderate fat-fed dog model, which has been shown to develop both subcutaneous and visceral adiposity and severe insulin resistance.
and the authors concluded:
Our results indicate that a diet enriched with a moderate amount of fat results in the development of both subcutaneous and visceral adiposity, hyperinsulinemia, and a modest degree of peripheral insulin resistance.
How did they achieve these results? To quote Peter (of Hyperlipid)
Cr@p in a bag: Total calories 3,885kcal/d
For "less cr@p in a bag but plus 2g/kg bacon grease": more like 3,945kcal/d
This is for a 27kg dog sitting in a cage.
Go on, read that again; 3,945kcal/d. I'm not joking.
The real trick of course, is to blame the subsequent insulin resistance on saturated fat.
So this is another study where the introduction and discussion are utterly divorced from the methods and the results (and from reality). It's worth just flicking through the methods and, in your mind's eye, look at how much money was used on these dogs. A clinical MRI was around about £1000 a shot in the UK Home Counties in 2009.
This study was funded in the US of course, guess we all look forward to such sterling research with our tarp funds.
Where's PETA when you need them?